Exact unconditional tests for a 2 x 2 matched-pairs design.

More powerful exact noninferiority and equivalence tests based on binary matched pairs

Assessing the therapeutic noninferiority or equivalence of one medical treatment compared to another is often based on the difference of response rates from a matched binary pairs design. This paper develops new exact unconditional tests for noninferiority and equivalence that are more powerful than available alternatives. There are three new elements presented in this paper. First we introduce...

An Unconditional Exact Test For Small Samples Matched Binary Pairs

Recommended tests for association in 2 x 2 tables.

The asymptotic Pearson's chi-squared test and Fisher's exact test have long been the most used for testing association in 2x2 tables. Unconditional tests preserve the significance level and generally are more powerful than Fisher's exact test for moderate to small samples, but previously were disadvantaged by being computationally demanding. This disadvantage is now moot, as software to facilit...

Tests for the homogeneity of two binomial proportions in extremely unbalanced 2 x 2 contingency tables.

Asymptotic tests such as the Pearson chi-square test are unreliable for testing the homogeneity of two binomial probabilities in extremely unbalanced cases. Two exact tests (conditional and unconditional) are available as alternatives and can be implemented easily in StatXact 6.0. In equal sample cases it is well known that the unconditional exact test is more powerful than the conditional exac...

The McNemar test for binary matched-pairs data: mid-p and asymptotic are better than exact conditional

BACKGROUND Statistical methods that use the mid-p approach are useful tools to analyze categorical data, particularly for small and moderate sample sizes. Mid-p tests strike a balance between overly conservative exact methods and asymptotic methods that frequently violate the nominal level. Here, we examine a mid-p version of the McNemar exact conditional test for the analysis of paired binomia...